Clarke’s Isolation and Identification of Drugs

Well over two million medical students, doctors and other health professionals around the globe have owned a copy of Davidson’s Principles and Practice of Medicine since it was first published over 70 years ago. Now in its 24th Edition, this thoroughly updated textbook describes the pathophysiology and clinical features of the most frequently encountered conditions in the major specialties of adult medicine, and explains how to recognise, investigate, diagnose and manage them. Taking its origins from Sir Stanley Davidson’s much-admired lecture notes, Davidson’s has endured because it keeps pace with how modern medicine is taught and provides a wealth of trusted information in an easy-to-read, concise and beautifully illustrated format.

Key features:

• • Part 1 ‘Fundamentals of Medicine’ – provides an account of the principles of genetics, immunology, infectious diseases, population health, oncology and pain management, along with a discussion of the core principles behind clinical decision-making and good prescribing.

• • Part 2 ‘Emergency and Critical Care Medicine’ – covers medical emergencies in poisoning, envenomation and medicine in austere environments, as well as common presentations in acute medicine and the recognition and management of the critically ill.

• • Part 3 ‘Clinical Medicine’– covers the major medical specialties, each thoroughly revised and brought fully up to date. A new section on COVID-19 has been added and the impact of this infection is described throughout the book.

• • Clinical Examination overviews – extended and updated to summarise the main elements for each system.

• • Presenting Problems sections – provide a clear pathway for the assessment of and approach to the most common complaints in each specialty.

• • Practice Point summaries – detail the practical skills that medical students and junior doctors must acquire.

• • Emergency boxes – emphasise the core knowledge needed to manage acutely ill patients.

• • In Old Age, In Pregnancy and In Adolescence boxes – highlight differences in the practice of medicine in these patient groups, and illustrate the interfaces between medical, obstetric and paediatric services.

• • The text is extensively illustrated – with over 1000 diagrams, clinical photographs, and radiology and pathology images.

• The global perspective is enhanced by an International Advisory Board of experts from 11 countries and by leading authors from around the world.

This book covers in detail the mechanisms for how energy is managed in the human body. The basic principles that elucidate the reactivity and physical interactions of matter are addressed and quantified with simple approaches. Three-dimensional representations of molecules are presented throughout the book so molecules can be viewed as unique entities in their shape and function.

The book is focused on the molecular mechanisms of cellular processes in the context of human physiological situations such as fasting, feeding and physical exercise, in which metabolic regulation is highlighted. Furthermore the book uses key historical experiments that opened up new concepts in Biochemistry to further illustrate how the human body functions at molecular level, helping students to appreciate how scientific knowledge emerges.

This book also:

• Elucidates the foundations of the molecular events of life
  

Uses key historical experiments that opened up new concepts in Biochemistry to further illustrate how the human body functions at molecular level, helping students to appreciate how scientific knowledge emerges

• Provides realistic representations of molecules throughout the book
  

Advance Praise for Integrative Human Biochemistry

“This textbook provides a modern and integrative perspective of human biochemistry and will be a faithful companion to health science students following curricula in which this discipline is addressed. This textbook will be a most useful tool for the teaching community.”

Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease.

The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action.  More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished.

This edition is enhanced by timely new content:

• NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis
• Expanded coverage of cardiovascular disease, with separate chapters on  myocardial ischemia, hypertension, and heart failure 
• Increased emphasis on cellular signaling pathways involved in drug action
• Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips
• Chapter Content Outlines at the beginning of each chapter
• Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter